1998•Journal of Labelled Compounds and RadiopharmaceuticalsRequires access

Simple methods for the labelling of N-methyl amines using isotopically labelled methyl iodide

Ian Fellows, Richard M. Carr, Nigel deboeck, Stephen H. Montgomery, Ian Waterhouse, Derek R. Sutherland

Abstract

Methods for the synthesis of isotopically labelled N-methyl amines using the target amine and isotopically labelled methyl iodide in a quaternisation/dequaternisation strategy are described. The method has been further refined to allow the synthesis of such amines without any isotopic dilution. Copyright © 1998 John Wiley & Sons, Ltd.

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Key concepts: Chemistry, Labelling, Methyl iodide, Iodide, Amine gas treating, Isotope dilution, Isotopic labeling, Organic chemistry