John W. Bunting, William G. Meathrel
Abstract
Contrary to previous reports, the methylation of quinazoline with methyl iodide has been shown to produce both 1-methylquinazolinium iodide and 3-methylquinazolinium iodide. These quaternary salts are formed in the ratio of 5:1 in favor of the latter isomer.
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Contrary to previous reports, the methylation of quinazoline with methyl iodide has been shown to produce both 1-methylquinazolinium iodide and 3-methylquinazolinium iodide. These quaternary salts are formed in the ratio of 5:1 in favor of the latter isomer.
Key concepts: Chemistry, Methyl iodide, Iodide, Quinazoline, Methylation, Iodine, Medicinal chemistry, Organic chemistry