2007•SEIBUTSU BUTSURI KAGAKUOpen access

Advanced systems of mass spectrometry for proteomics.

Tosifusa Toda

Abstract

Proteomics has been established by combination of two-dimensional gel electrophoresis and mass spectrometry. The most significant advantage of proteomics over the conventional protein analysis is the high-throughput performance in comprehensive analysis of almost all proteins expressed in a specific tissue or cell type under a given condition. Mass spectrometry plays important roles not only in identification of proteins separated by two-dimensional gel electrophoresis but also in analysis of post-translational modifications.

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Available abstract

Key concepts: Proteomics, Mass spectrometry, Two-dimensional gel electrophoresis, Chemistry, Gel electrophoresis, Bottom-up proteomics, Chromatography, Posttranslational modification