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Mass Spectrometry: Analysis of Two‐dimensional Protein Gels

Hanjo Lim, John R. Yates

Abstract

Abstract Matrix‐assisted laser desorption/ionization mass spectrometry and electrospray tandem mass spectrometry, coupled with liquid chromatography, enable high‐throughput protein identification and further characterization, such as post‐translational modification, of proteins, after initial separation by two‐dimensional gel electrophoresis.

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Key concepts: Protein mass spectrometry, Mass spectrometry, Chromatography, Chemistry, Sample preparation in mass spectrometry, Capillary electrophoresis–mass spectrometry, Top-down proteomics, Tandem mass spectrometry