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2012•Journal of Biomaterials and NanobiotechnologyOpen access

In Vitro Evaluation of Polyurethane-Chitosan Scaffolds for Tissue Engineering

Imelda Olivas-Armendáriz, Perla E. García‐Casillas, Adriana Martel Estrada, A. Martínez‐Villafañe, Laura A. A. de la Rosa, Carlos A. Perez

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Abstract

In this work the use of Polyurethane (PU)-Chitosan(CH) scaffolds prepared by thermal induced phase separation (TIPS) for osteoblast proliferation and bone mineralization is described. Primary rat calvaria osteoblasts were seeded in the scaffolds and it was shown that supported cell adhesion and growth. The behavior osteoblast cells growing in the scaffold in function of the different ratio of PU and CH is presented. The results showed that TIPS is an appropriate technique for the production of PU-CH scaffolds with high potential for application as cell scaffolds in bone tissue engineering.

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What this paper is about

In this work the use of Polyurethane (PU)-Chitosan(CH) scaffolds prepared by thermal induced phase separation (TIPS) for osteoblast proliferation and bone mineralization is described. Primary rat calvaria osteoblasts were seeded in the scaffolds and it was shown that supported cell adhesion and growth. The behavior osteoblast cells growing in the scaffold in function of the different ratio of PU and CH is presented. The results showed that TIPS is an appropriate technique for the production of PU-CH scaffolds with high potential for application as cell scaffolds in bone tissue engineering.

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Available abstract

In this work the use of Polyurethane (PU)-Chitosan(CH) scaffolds prepared by thermal induced phase separation (TIPS) for osteoblast proliferation and bone mineralization is described. Primary rat calvaria osteoblasts were seeded in the scaffolds and it was shown that supported cell adhesion and growth. The behavior osteoblast cells growing in the scaffold in function of the different ratio of PU and CH is presented. The results showed that TIPS is an appropriate technique for the production of PU-CH scaffolds with high potential for application as cell scaffolds in bone tissue engineering.

Key concepts: Calvaria, Osteoblast, Scaffold, Chitosan, Tissue engineering, Polyurethane, Materials science, Biomedical engineering

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