1994•PathophysiologyOpen access
Effect of rebamipide, a novel anti-ulcer agent, on acute gastric mucosal injury induced by ischemia-reperfusion in rats
Yuji Naito, Toshikazu Yoshikawa, Kiichi Matsuyama, Nobuaki Yagi, Yasunari Nakamura, S Nishimura, Motoharu Kondo
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Abstract
The protective effect of a novel anti-ulcer agent rebamipide on the acute gastric mucosal injury induced by ischemia-reperfusion was studied in rats. Ischemia/reperfusion injury was produced on the rat stomach by applying a small clamp to the celiac artery for 30 min and by removal of the clamp for 60 min. The decrease in the gastric mucosal blood flow was not influenced by the treatment with rebamipide. The increase in the total area of erosions on the stomach after ischemia-reperfusion and the increase in lipid peroxides in the gastric mucosa were significantly inhibited by the oral administration of rebamipide at doses of 30 and 100 mg/kg. These results suggest that the protective effect of rebamipide against the ischemia/reperfusion-induced aggravation of gastric mucosal injury may be the result of its inhibitory effect on lipid peroxidation.