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Expression of p38MAPK in rat stomach ischemia-reperfusion injury

Zhang Feng

Abstract

Objective:To study the role of p38MAPK in rat stomach ischemia-reperfusion injury.Methods:30 SD rats were randomly divided into control group and stomach ischemia-reperfusion injury group.Rats were executed to death at 0,0.5,1,3,6,12 h after stomach ischemia-reperfusion injury and the stomach specimens were taken for pathologic examination.The expression of p38MAPK was detected by the immunohistochemical method.Results:The expression of p38MAPK in the stomach ischemia reperfusion injury was increased,which was significantly increased after 0.5h of stomach ischemia-reperfusion injury,reached the high peak till 1 h,declined till reperfusion 3 h,and then again rose and maintained at relatively high level till reperfusion 12 h.Conclusion:p38MAPK play an important role in the process of stomachs ischemia-reperfusion injury.

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Key concepts: Medicine, Stomach, Ischemia, Reperfusion injury, Immunohistochemistry, Anesthesia, Pathology, Internal medicine