2009Acta HaematologicaRequires access

Lipid Peroxidation in Human Erythrocytes in Tocopherol Deficiency

G. R. Tudhope, J. G. Hopkins

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Abstract

Lipid peroxidation following exposure to H2O2 vapour was abnormally great in the erythrocytes from certain patients with low plasma tocopherol concentrations. Following treatment of such patients with tocopherol, erythrocyte lipid peroxidation was markedly reduced. The in vitro addition of tocopherol reduced lipid peroxidation in erythrocytes from both normal subjects and tocopherol-deficient patients.

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What this paper is about

Lipid peroxidation following exposure to H2O2 vapour was abnormally great in the erythrocytes from certain patients with low plasma tocopherol concentrations. Following treatment of such patients with tocopherol, erythrocyte lipid peroxidation was markedly reduced. The in vitro addition of tocopherol reduced lipid peroxidation in erythrocytes from both normal subjects and tocopherol-deficient patients.

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Available abstract

Lipid peroxidation following exposure to H2O2 vapour was abnormally great in the erythrocytes from certain patients with low plasma tocopherol concentrations. Following treatment of such patients with tocopherol, erythrocyte lipid peroxidation was markedly reduced. The in vitro addition of tocopherol reduced lipid peroxidation in erythrocytes from both normal subjects and tocopherol-deficient patients.

Key concepts: Lipid peroxidation, Tocopherol, Vitamin E, Chemistry, Biochemistry, alpha-Tocopherol, In vitro, Antioxidant

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