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Comparative studies on the camptothecin content fromNothapodytes foetidaandOphiorrhizaspecies

G. Roja

Abstract

Camptothecin is an anticancer quinoline alkaloid effective against colon cancer. It acts by inhibition of the enzyme DNA topoisomerase I. A comparative study of camptothecin from the indigenous plants namely Nothapodytes foetida, Ophiorrhiza mungos and Ophiorrhiza rugosa indicated highest yields of camptothecin and 9-methoxy camptothecin in N. foetida. The other two plants O. mungos and O. rugosa contained low levels of alkaloids.

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Key concepts: Camptothecin, Quinoline, Chemistry, Alkaloid, Traditional medicine, Topoisomerase, Stereochemistry, Enzyme