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2004•Bioorganic & Medicinal ChemistryRequires access

On the role of E-ring oxygen atoms in the binding of camptothecin to the topoisomerase I–DNA covalent binary complex

Nicolas J. Rahier, Brian M. Eisenhauer, Rong Gao, Shannon J. Thomas, Sidney M. Hecht

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Key concepts: Topoisomerase, Camptothecin, Chemistry, Stereochemistry, DNA, Covalent bond, Ternary complex, Cytotoxicity

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On the role of E-ring oxygen atoms in the binding of camptothecin to the topoisomerase I–DNA covalent binary complex — Research Paper | ScholarLens