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1971•The Journal of Clinical Endocrinology & MetabolismRequires access

INCREASED SERUM PROLACTIN AFTER ADMINISTRATION OF SYNTHETIC THYROTROPIN RELEASING HORMONE (TRH) IN MAN1

LAURENCE S. JACOBS, Peter J. Snyder, John F. Wilber, Robert D. Utiger, William H. Daughaday

Open publisher page 318 citations

Abstract

Tea normal volunteers received 100 to 800 ug of TRH intravenously. Serum prolactin was measured by a specific radioimmunoassay before and at intervals after TRH administration. Serum prolactin began to rise within 5 minutes and was maximal after 15 to 20 minutes. The mean peak response at 15 minutes was 11 times the fasting level. Serum prolactin had returned to the baseline by 180 minutes. It is concluded that TRH may be closely related to prolactin releasing factors in crude hypothalamic extracts.

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What this paper is about

Tea normal volunteers received 100 to 800 ug of TRH intravenously. Serum prolactin was measured by a specific radioimmunoassay before and at intervals after TRH administration. Serum prolactin began to rise within 5 minutes and was maximal after 15 to 20 minutes. The mean peak response at 15 minutes was 11 times the fasting level. Serum prolactin had returned to the baseline by 180 minutes. It is concluded that TRH may be closely related to prolactin releasing factors in crude hypothalamic extracts.

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OpenAlex reports 318 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Tea normal volunteers received 100 to 800 ug of TRH intravenously. Serum prolactin was measured by a specific radioimmunoassay before and at intervals after TRH administration. Serum prolactin began to rise within 5 minutes and was maximal after 15 to 20 minutes. The mean peak response at 15 minutes was 11 times the fasting level. Serum prolactin had returned to the baseline by 180 minutes. It is concluded that TRH may be closely related to prolactin releasing factors in crude hypothalamic extracts.

Key concepts: Prolactin, Thyrotropin-releasing hormone, Endocrinology, Internal medicine, Radioimmunoassay, Hormone, Serum concentration, Medicine

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INCREASED SERUM PROLACTIN AFTER ADMINISTRATION OF SYNTHETIC THYROTROPIN RELEASING HORMONE (TRH) IN MAN1 — Research Paper | ScholarLens