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Uricase Inhibition in the Rat by s-Triazines: An Animal Model for Hyperuricemia and Hyperuricosuria

W J Johnson, B. Stavrić, A. Chartrand

Open publisher page 81 citations

Abstract

Oxonic acid and allantoxaidine were potent in vivo inhibitors of uricase. Oxonic acid, when fed to rats or injected intraperitoneally, produced a marked increase in blood plasma urate levels and urinary uric acid output with a concomitant decrease in urinary allantoin excretion. Addition of 5% oxonic acid plus 1% uric acid to the diet resulted in a 22-fold increase in urinary uric acid by day 23 of treatment with deposition of uric acid in the kidney tubules. The oxonic acid-treated rat may serve as a useful animal model for the study of hyperuricemia and hyperuricosuria.

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What this paper is about

Oxonic acid and allantoxaidine were potent in vivo inhibitors of uricase. Oxonic acid, when fed to rats or injected intraperitoneally, produced a marked increase in blood plasma urate levels and urinary uric acid output with a concomitant decrease in urinary allantoin excretion. Addition of 5% oxonic acid plus 1% uric acid to the diet resulted in a 22-fold increase in urinary uric acid by day 23 of treatment with deposition of uric acid in the kidney tubules. The oxonic acid-treated rat may serve as a useful animal model for the study of hyperuricemia and hyperuricosuria.

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OpenAlex reports 81 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Oxonic acid and allantoxaidine were potent in vivo inhibitors of uricase. Oxonic acid, when fed to rats or injected intraperitoneally, produced a marked increase in blood plasma urate levels and urinary uric acid output with a concomitant decrease in urinary allantoin excretion. Addition of 5% oxonic acid plus 1% uric acid to the diet resulted in a 22-fold increase in urinary uric acid by day 23 of treatment with deposition of uric acid in the kidney tubules. The oxonic acid-treated rat may serve as a useful animal model for the study of hyperuricemia and hyperuricosuria.

Key concepts: Hyperuricosuria, Uric acid, Allantoin, Hyperuricemia, Chemistry, Urinary system, Endocrinology, Internal medicine

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