Paosphorothioate Analogues of Inositol Phosphates
Allan M. Cooke, Leroy James, Stefan R. Nahorski, Barry V. L. Potter
Abstract
Allan M. Cooke, Leroy James, Stefan R. Nahorski, Barry V. L. Potter
Abstract
Novel analogues of the intracellular second messenger D-myo-inositol 1,4,5-trisphosphate, which possess phosphorothioate groups in place of phosphate groups have been synthesized. They exhibit unusual biological properties which will be of considerable application in understanding the phosphoinositide cycle.
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Novel analogues of the intracellular second messenger D-myo-inositol 1,4,5-trisphosphate, which possess phosphorothioate groups in place of phosphate groups have been synthesized. They exhibit unusual biological properties which will be of considerable application in understanding the phosphoinositide cycle.
Key concepts: Inositol, Inositol phosphate, Second messenger system, Intracellular, Phosphate, Chemistry, Inositol trisphosphate receptor, Biochemistry