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2014•Arthritis Research & TherapyOpen access

Development of anti-citrullinated protein antibody and rheumatoid factor isotypes prior to the onset of rheumatoid arthritis

Wouter H Bos, Lotte Arwen van de Stadt, Azita Sohrabian, Johan Rönnelid, Dirkjan van Schaardenburg

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Abstract

We and others have previously shown that the development of rheumatoid arthritis (RA) is preceded by IgG anti-citrullinated protein antibody (ACPA) and rheumatoid factor (RF) [ 1 , 2 ]. Furthermore, it was shown that other isotypes of ACPA (IgA and, to a lesser extent, the IgM isotype) also predate the onset of RA [ 3 ]. Moreover, smoking has been linked to the development of IgA ACPA in the preclinical phase [ 3 ].

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What this paper is about

We and others have previously shown that the development of rheumatoid arthritis (RA) is preceded by IgG anti-citrullinated protein antibody (ACPA) and rheumatoid factor (RF) [ 1 , 2 ]. Furthermore, it was shown that other isotypes of ACPA (IgA and, to a lesser extent, the IgM isotype) also predate the onset of RA [ 3 ]. Moreover, smoking has been linked to the development of IgA ACPA in the preclinical phase [ 3 ].

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Available abstract

We and others have previously shown that the development of rheumatoid arthritis (RA) is preceded by IgG anti-citrullinated protein antibody (ACPA) and rheumatoid factor (RF) [ 1 , 2 ]. Furthermore, it was shown that other isotypes of ACPA (IgA and, to a lesser extent, the IgM isotype) also predate the onset of RA [ 3 ]. Moreover, smoking has been linked to the development of IgA ACPA in the preclinical phase [ 3 ].

Key concepts: Rheumatoid arthritis, Rheumatoid factor, Rheumatology, Medicine, Immunology, Antibody, Internal medicine, Autoantibody

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