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Selective solid-phase extraction of phenylcarbamic acid derivatives from a rat serum by molecularly imprinted polymer

Miroslava Lachová, Jozef Lehotay, Ivan Skačáni, Jozef Cizmárik

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Abstract

Molecularly imprinted polymer (MIP) was synthesized using a non-covalent imprinting approach. Methacrylic acid was used as the functional monomer, acetonitrile was used as the porogen and 1-methyl-2-piperidinoethylester of 4-decyloxyphenylcarbamic acid as the imprint molecule (template). Imprinted polymer was utilized as the sorbents for solid-phase extraction (MISPE) to extract derivatives of alkoxyphenylcarbamic acid from spiked rat serum.

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What this paper is about

Molecularly imprinted polymer (MIP) was synthesized using a non-covalent imprinting approach. Methacrylic acid was used as the functional monomer, acetonitrile was used as the porogen and 1-methyl-2-piperidinoethylester of 4-decyloxyphenylcarbamic acid as the imprint molecule (template). Imprinted polymer was utilized as the sorbents for solid-phase extraction (MISPE) to extract derivatives of alkoxyphenylcarbamic acid from spiked rat serum.

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Available abstract

Molecularly imprinted polymer (MIP) was synthesized using a non-covalent imprinting approach. Methacrylic acid was used as the functional monomer, acetonitrile was used as the porogen and 1-methyl-2-piperidinoethylester of 4-decyloxyphenylcarbamic acid as the imprint molecule (template). Imprinted polymer was utilized as the sorbents for solid-phase extraction (MISPE) to extract derivatives of alkoxyphenylcarbamic acid from spiked rat serum.

Key concepts: Molecularly imprinted polymer, Methacrylic acid, Solid phase extraction, Molecular imprinting, Chromatography, Chemistry, Polymer, Extraction (chemistry)

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