2005Clinical Nuclear MedicineRequires access

A Patient with Acromegaly Presenting with Polyostotic Fibrous Dysplasia on Bone Scan: McCune-Albright Syndrome

Holger Brockmann, Alexius Joe, H. Palmedo, Hans‐Juergen Biersack

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Abstract

We report a 43-year-old male with acromegaly who underwent pituitary adenomectomy in 1989. Recently, the patient presented with pain in the right hip. X-ray examination showed multiple cystic lesions in the right pelvis and femur. We present the consecutively performed Tc-99m HDP bone scan that shows features of polyostotic fibrous dysplasia. The coincidence of acromegaly with fibrous dysplasia established the diagnosis of an uncommon manifestation of the McCune-Albright Syndrome. This is typically characterized by fibrous dysplasia, café-au-lait macules and hyperfunctioning endocrinopathies.

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What this paper is about

We report a 43-year-old male with acromegaly who underwent pituitary adenomectomy in 1989. Recently, the patient presented with pain in the right hip. X-ray examination showed multiple cystic lesions in the right pelvis and femur. We present the consecutively performed Tc-99m HDP bone scan that shows features of polyostotic fibrous dysplasia. The coincidence of acromegaly with fibrous dysplasia established the diagnosis of an uncommon manifestation of the McCune-Albright Syndrome. This is typically characterized by fibrous dysplasia, café-au-lait macules and hyperfunctioning endocrinopathies.

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OpenAlex reports 4 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

We report a 43-year-old male with acromegaly who underwent pituitary adenomectomy in 1989. Recently, the patient presented with pain in the right hip. X-ray examination showed multiple cystic lesions in the right pelvis and femur. We present the consecutively performed Tc-99m HDP bone scan that shows features of polyostotic fibrous dysplasia. The coincidence of acromegaly with fibrous dysplasia established the diagnosis of an uncommon manifestation of the McCune-Albright Syndrome. This is typically characterized by fibrous dysplasia, café-au-lait macules and hyperfunctioning endocrinopathies.

Key concepts: Polyostotic fibrous dysplasia, McCune–Albright syndrome, Medicine, Fibrous dysplasia, Acromegaly, Pelvis, GNAS complex locus, Radiology

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