Hyperthyroidism with Fibrous Dysplasia: An unusual presentation of McCune-Albright syndrome
Mohammad Hayat Bhat, Sanjay Kumar Bhadada, Pinaki Dutta, Anil Bhansali, Bhagwant Rai Mittal
Abstract
Mohammad Hayat Bhat, Sanjay Kumar Bhadada, Pinaki Dutta, Anil Bhansali, Bhagwant Rai Mittal
Abstract
McCune-Albright Syndrome (MAS) is a sporadic disorder characterized by a triad of poly/monostotic fibrous dysplasia, café-au-lait macules, and hyperfunctioning endocrinopathies. Hyperthyroidism as a manifestation of endocrine hyperfunction in MAS is uncommon. We report a patient who had polyostotic fibrous dysplasia with multiple pathological fractures and hyperthyroidism. She underwent surgery for hyperthyroidism and received pamidronate therapy with remarkable relief in bone pains and without any new fractures during her subsequent follow up of 3 years.
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McCune-Albright Syndrome (MAS) is a sporadic disorder characterized by a triad of poly/monostotic fibrous dysplasia, café-au-lait macules, and hyperfunctioning endocrinopathies. Hyperthyroidism as a manifestation of endocrine hyperfunction in MAS is uncommon. We report a patient who had polyostotic fibrous dysplasia with multiple pathological fractures and hyperthyroidism. She underwent surgery for hyperthyroidism and received pamidronate therapy with remarkable relief in bone pains and without any new fractures during her subsequent follow up of 3 years.
Key concepts: McCune–Albright syndrome, Polyostotic fibrous dysplasia, Fibrous dysplasia, Medicine, Presentation (obstetrics), Endocrine system, Pathological, Osteitis fibrosa cystica