ScholarLens Back to search
1985•Journal of Pharmacobio-DynamicsOpen access

The use of human tumor clonogenic assay in predicting combination effect of cisplatin plus vindesine in carcinoma of the lung.

Fumihiko Kanzawa, Yuka Matsushima, Jun-ichi Ishihara, Eiji Shimizu, Yasutsuna Sasaki, Nagahiro Saijo, Naoto Miyazawa

Open full text 2 citations

Abstract

By using a human tumor clonogenic assay, cisplatin plus vindesine regimen was evaluated in 17 carcinoma of the lung. The cisplatin (0.2 microgram/ml) plus vindesine (0.005 microgram/ml) combination was synergistic and additive cell killing in 10 and 4, respectively, of 17 specimens. On the other hand, only three specimens showed antagonistic cell killing from this drug combination. Our results indicated that this in vitro assay provides a new method which can predict the effects of the combination of drugs on individual patients.

Open-access reader

About this research paper

What this paper is about

By using a human tumor clonogenic assay, cisplatin plus vindesine regimen was evaluated in 17 carcinoma of the lung. The cisplatin (0.2 microgram/ml) plus vindesine (0.005 microgram/ml) combination was synergistic and additive cell killing in 10 and 4, respectively, of 17 specimens. On the other hand, only three specimens showed antagonistic cell killing from this drug combination. Our results indicated that this in vitro assay provides a new method which can predict the effects of the combination of drugs on individual patients.

Why it matters

OpenAlex reports 2 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

By using a human tumor clonogenic assay, cisplatin plus vindesine regimen was evaluated in 17 carcinoma of the lung. The cisplatin (0.2 microgram/ml) plus vindesine (0.005 microgram/ml) combination was synergistic and additive cell killing in 10 and 4, respectively, of 17 specimens. On the other hand, only three specimens showed antagonistic cell killing from this drug combination. Our results indicated that this in vitro assay provides a new method which can predict the effects of the combination of drugs on individual patients.

Key concepts: Vindesine, Clonogenic assay, Cisplatin, Microgram, In vitro, Regimen, Pharmacology, Cancer research

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
The use of human tumor clonogenic assay in predicting combination effect of cisplatin plus vindesine in carcinoma of the lung. — Research Paper | ScholarLens