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RECOVERY OF THE HEMOLYSIN RESPONSE IN MOUSE RADIATION CHIMERAS

GIOVANNA AGAROSSI, Gino Doria

Open publisher page 7 citations

Abstract

Recovery of the immune system of mouse radiation chimeras immunized with sheep red blood cells was estimated by enumeration of hemolysin-forming spleen cells and titration of serum hemolytic activity. Both estimates were found to attain normal values in isogenic chimeras. In allogenic chimeras the recovery of the hemolysin titer remained subnormal during the 5 months of observations, and it was attributed to insufficient number of hemolysin-forming cells in the spleen. The correlation between numbers of hemolysin-forming spleen cells and hemolysin titer was introduced as a new criterion to evaluate the recovery of the immune system of mouse radiation chimeras.

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What this paper is about

Recovery of the immune system of mouse radiation chimeras immunized with sheep red blood cells was estimated by enumeration of hemolysin-forming spleen cells and titration of serum hemolytic activity. Both estimates were found to attain normal values in isogenic chimeras. In allogenic chimeras the recovery of the hemolysin titer remained subnormal during the 5 months of observations, and it was attributed to insufficient number of hemolysin-forming cells in the spleen. The correlation between numbers of hemolysin-forming spleen cells and hemolysin titer was introduced as a new criterion to evaluate the recovery of the immune system of mouse radiation chimeras.

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OpenAlex reports 7 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Recovery of the immune system of mouse radiation chimeras immunized with sheep red blood cells was estimated by enumeration of hemolysin-forming spleen cells and titration of serum hemolytic activity. Both estimates were found to attain normal values in isogenic chimeras. In allogenic chimeras the recovery of the hemolysin titer remained subnormal during the 5 months of observations, and it was attributed to insufficient number of hemolysin-forming cells in the spleen. The correlation between numbers of hemolysin-forming spleen cells and hemolysin titer was introduced as a new criterion to evaluate the recovery of the immune system of mouse radiation chimeras.

Key concepts: Hemolysin, Spleen, Titer, Chimera (genetics), Immune system, Biology, Immunology, Microbiology

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