2000•Planta MedicaRequires access

α-Glycosidase Inhibitory Activity of Hexagalloylglucose from the Galls of Quercus infectoria

Jae-Kwan Hwang, Tae‐Wook Kong, Nam In Baek, Yu Ryang Pyun

Abstract

Hexagalloylglucose (3-O-digalloyl-1,2,4,6-tetra-O-galloyl-beta-D- glucose), which was isolated from the methanol extract of the galls of Quercus infectoria, significantly inhibited alpha-glycosidases such as sucrase, maltase and isomaltase. Its inhibitory activity was comparable to acarbose being used as a hypoglycemic agent, while the inhibitory activity on alpha-amylase was approximately 10 times lower than that of acarbose. The results indicate that, when compared to acarbose, hexagalloylglucose might reduce the side effects by reducing inhibition of alpha-amylase.

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Key concepts: Acarbose, Alpha-glucosidase, Maltase, Sucrase, Inhibitory postsynaptic potential, Chemistry, Glycoside hydrolase, Arbutin