1989•Chemical and Pharmaceutical BulletinOpen access

Synthesis and .ALPHA.-glucosidase-inhibiting activity of a new .ALPHA.-glucosidase inhibitor, 4-O-.ALPHA.-D-glucopyranosylmoranoline and its N-substituted derivatives.

Yoshiaki Yoshikuni, Yohji Ezure, Takashi Seto, Kazuya Mori, Masayoshi Watanabe, Hiroshi Enomoto

Abstract

Various N-substituted derivatives of 4-O-alpha-D-glucopyranosylmoranoline have been synthesized, and their inhibitory activities against rabbit sucrase and maltase have been measured, as well as their effects on postprandial hyperglycemia in the sucrose-loaded rat, 4-O-alpha-D-Glucopyranosylmoranoline was also shown to have potent hypoglycemic activity in starch-loaded dogs.

Open-access reader

About this research paper

What this paper is about

Why it matters

OpenAlex reports 32 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Chemistry, Alpha (finance), Alpha-glucosidase, Stereochemistry, Enzyme inhibitor, Biochemistry, Enzyme, Patient satisfaction