Autoradiographic Studies of Distribution in the Liver of198Au and99mTc-Sulfur Colloids

There are observable differences in the way in which the liver handles 198Au and 99mTc-sulfur colloids. Studies were made with serial autoradiography following intravenous injection of these two colloids into mice. 198Au colloid passes through three distinct stages of phagocytosis by Kupffer's cells. In sharp contrast, 99mTc-sulfur colloid does not.