2006•BiokemistriRequires access

Enhancement of acetaminophen overdosage-induced hepatotoxicity by coconut water

Okey A. Ojiako, H. U. Nwanjo, Emma A Nwokoro

Abstract

Coconut water was investigated for its possible effect on the acetaminophen (paracetamol) overdosage-induced hepatotoxicity in three groups of albino Wistar rats. Administration of the minimum toxic dose of paracetamol (150mg/kg body weight) to animals (group II) produced significantly (P≤0.05) higher levels of alanine aminotransferase (ALT) and alkaline phosphatase (ALP) activities when compared to the control group (group I). There was however no significant (P≤0.05) aspartate aminotransferase (AST) activity. Significantly (p

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Acetaminophen, Alkaline phosphatase, Alanine aminotransferase, Chemistry, Pharmacology, Body weight, Medicine, Biochemistry