Effect of glucurolactone on metabolism of acetaminophen and its liver impairment in mice

AIM To study the effect of glucurolactone on metabolism of acetaminophen and whether there is protective effect on liver impairment induced by acetaminophen. METHODS After ip 150 mg·kg -1 acetaminophen and glucurolactone simultaneously, the variation of metabolic ratio was determined. The effect of liver impairment induced by acetaminophen was observed while acetaminophen and glucurolactone were administered ip with inducing or simultane ous administering methods. RESULTS Glucurolactone had no effect on metabolism of acetaminophen and no protecting action on liver impairment induced by acetaminophen in Kunming mice. CONCLUSION Glucurolactone has no direct detoxification to the toxicity induced by acetaminophen in mice.