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2-(Trimethylsilyl)phenyl Trifluoromethanesulfonate

Diego Peña

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Abstract

All articles of this category Although benzyne ( 4 ) has been widely used in organic synthesis, there are relatively few ways of generating it under mild conditions from readily available chemicals. Subjecting 2-(trimethylsilyl)phenyl trifluoromethanesulfonate ( 3 ) to fluoride-induced 1,2-elimination generates benzyne conveniently at room temperature without the use of strong bases or oxidants.

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What this paper is about

All articles of this category Although benzyne ( 4 ) has been widely used in organic synthesis, there are relatively few ways of generating it under mild conditions from readily available chemicals. Subjecting 2-(trimethylsilyl)phenyl trifluoromethanesulfonate ( 3 ) to fluoride-induced 1,2-elimination generates benzyne conveniently at room temperature without the use of strong bases or oxidants.

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Available abstract

All articles of this category Although benzyne ( 4 ) has been widely used in organic synthesis, there are relatively few ways of generating it under mild conditions from readily available chemicals. Subjecting 2-(trimethylsilyl)phenyl trifluoromethanesulfonate ( 3 ) to fluoride-induced 1,2-elimination generates benzyne conveniently at room temperature without the use of strong bases or oxidants.

Key concepts: Aryne, Chemistry, Trifluoromethanesulfonate, Trimethylsilyl trifluoromethanesulfonate, Trimethylsilyl, Fluoride, Organic chemistry, Medicinal chemistry

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