1983•Chemistry LettersRequires access

FLUORIDE-INDUCED 1,2-ELIMINATION OF O -TRIMETHYLSILYLPHENYL TRIFLATE TO BENZYNE UNDER MILD CONDITIONS

Yoshio Himeshima, Takaaki Sonoda, Hiroshi Kobayashi

Abstract

Abstract Fluoride-induced 1,2-elimination of o-trimethylsilylphenyl triflate provided a convenient route to benzyne under mild conditions where detriflation from an intermediary aryl anion appeared to occur in preference to protonation even in the presence of alcohols.

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Key concepts: Chemistry, Aryne, Trifluoromethanesulfonate, Fluoride, Protonation, Aryl, Medicinal chemistry, Ion