2004•Pharmaceutical ResearchRequires access

Metabolism and Disposition of the HIV-1 Protease Inhibitor Lopinavir (ABT-378) Given in Combination with Ritonavir in Rats, Dogs, and Humans

Gondi N. Kumar, Venkata K. Jayanti, Marianne K. Johnson, John T. Uchic, Samuel B. Thomas, Ronald Demos Lee, Brian A. Grabowski, Hing Leung Sham, Dale J. Kempf, Jon F. Denissen, Kennan C. Marsh, Eugene Sun, Stanley Roberts

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Key concepts: Lopinavir, Ritonavir, Pharmacokinetics, Chemistry, Pharmacology, Metabolism, Lopinavir/ritonavir, Drug metabolism