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2011•Journal of BacteriologyOpen access

Genome Sequence of Mycobacterium bovis BCG Moreau, the Brazilian Vaccine Strain against Tuberculosis

Leonardo Henrique Ferreira Gomes, Thomas D. Otto, Érico A. Vasconcellos, Patrícia Mello Ferrão, Renata Martins Maia, Aline dos Santos Moreira, Marcelo Alves Ferreira, L.R.R. Castello-Branco, Wim Degrave, Leila Mendonça-Lima

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Abstract

Mycobacterium bovis bacillus Calmette-Guérin (BCG) is the only vaccine available against tuberculosis, and the strains used worldwide represent a family of daughter strains with distinct genotypic characteristics. Here we report the complete genome sequence of M. bovis BCG Moreau, the strain in continuous use in Brazil for vaccine production since the 1920s.

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Mycobacterium bovis bacillus Calmette-Guérin (BCG) is the only vaccine available against tuberculosis, and the strains used worldwide represent a family of daughter strains with distinct genotypic characteristics. Here we report the complete genome sequence of M. bovis BCG Moreau, the strain in continuous use in Brazil for vaccine production since the 1920s.

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Available abstract

Mycobacterium bovis bacillus Calmette-Guérin (BCG) is the only vaccine available against tuberculosis, and the strains used worldwide represent a family of daughter strains with distinct genotypic characteristics. Here we report the complete genome sequence of M. bovis BCG Moreau, the strain in continuous use in Brazil for vaccine production since the 1920s.

Key concepts: Mycobacterium bovis, Biology, BCG vaccine, Whole genome sequencing, Strain (injury), Virology, Microbiology, Mycobacterium tuberculosis

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