2011Journal of BacteriologyOpen access

Whole-Genome Sequences of Four Mycobacterium bovis BCG Vaccine Strains

Yuanlong Pan, Xi Yang, Jia Duan, Na Lü, Andrea S. Leung, Vanessa Tran, Yongfei Hu, Na Wu, Di Liu, Zhiming Wang, Xuping Yu, Chen Chen, Yuanyuan Zhang, Kanglin Wan, Jun Liu, Baoli Zhu

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Abstract

Mycobacterium bovis Bacille Calmette-Guérin (BCG) is the only vaccine available against tuberculosis (TB). A number of BCG strains are in use, and they exhibit biochemical and genetic differences. We report the genome sequences of four BCG strains representing different lineages, which will help to design more effective TB vaccines.

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What this paper is about

Mycobacterium bovis Bacille Calmette-Guérin (BCG) is the only vaccine available against tuberculosis (TB). A number of BCG strains are in use, and they exhibit biochemical and genetic differences. We report the genome sequences of four BCG strains representing different lineages, which will help to design more effective TB vaccines.

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OpenAlex reports 37 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Mycobacterium bovis Bacille Calmette-Guérin (BCG) is the only vaccine available against tuberculosis (TB). A number of BCG strains are in use, and they exhibit biochemical and genetic differences. We report the genome sequences of four BCG strains representing different lineages, which will help to design more effective TB vaccines.

Key concepts: Mycobacterium bovis, Biology, BCG vaccine, Mycobacterium tuberculosis, Whole genome sequencing, Microbiology, Genome, Tuberculosis

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