1996•Journal of Molecular BiologyRequires access

Isolation of Picomolar Affinity Anti-c-erbB-2 Single-chain Fv by Molecular Evolution of the Complementarity Determining Regions in the Center of the Antibody Binding Site

Robert J. Schier, Adrian M. McCall, Gregory Paul Adams, Keith W. Marshall, Hanne Merritt, Michael T. Yim, Robert S. Crawford, Louis M. Weiner, Cara Berman Marks, James D. Marks

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Key concepts: Affinity maturation, Complementarity determining region, Immunoglobulin light chain, Phage display, Molecular biology, Antibody, Mutant, Biology