2005•Protein and Peptide LettersRequires access

Crystal Structure of Non-Fused Glutathione S-Transferase from Schistosoma 709 japonicum in Complex with Glutathione

Inari Kursula, Anthony M. Heape, Petri Kursula

Abstract

Schistosoma japonicum glutathione S-transferase (SjGST) is a common fusion tag in recombinant protein production, and its 3-dimensional structure has been studied in the context of drug design. We have determined the crystal structure of non-fused SjGST complexed with glutathione, and compare it to complexes between glutathione and SjGST fusion proteins. Keywords: glutathione, gst, crystal structure, fusion protein, schistosoma japonicum

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Key concepts: Schistosoma japonicum, Glutathione, Glutathione S-transferase, Fusion protein, Context (archaeology), Chemistry, Transferase, Glutathione transferase