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Cytopathic Effect of Canine Distemper Virus in Tissue Culture

David T. Karzon, Robert H. Bussell

Abstract

A characteristic cytopathic effect was obtained with canine distemper virus (Onderstepoort strain) propagated in chick embryo fibroblast monolayer tissue culture. In limiting dilutions the lesions were focal. The titer at the 20th tissue culture passage was approximately 10(5) TCD(50)/ml. Cytopathogenicity was specifically inhibited by distemper immune serum. Minute plaques were produced under agar overlay.

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Key concepts: Canine distemper, Cytopathic effect, Virus, Titer, Tissue culture, Biology, Virology, Fibroblast