1976•Arthritis & RheumatismOpen access

Prednisone and azathioprine compared to prednisone plus low-dose azathioprine and cyclophosphamide in the treatment of diffuse lupus nephritis

Ellen M. Ginzler, Herbert S. Diamond, Maria Guttadauria, David S. Kaplan

Abstract

A 1-year double-blind crossover study comparing prednisone and azathioprine to prednisone plus low-dose azathioprine and cyclophosphamide was carried out in 14 patients with diffuse lupus nephritis. Low-dose triple therapy had no apparent therapeutic advantage over prednisone plus azathioprine. Cyclophosphamide-induced ovarian failure and hematuria were not avoided by its use in low dose.

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Available abstract

Key concepts: Azathioprine, Prednisone, Cyclophosphamide, Medicine, Lupus nephritis, Gastroenterology, Internal medicine, Dermatology