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1970•Acta Physiologica ScandinavicaRequires access

Local Degranulation of Individual Rat Peritoneal Mast Cells Induced by Compound 48/80

Bertil Diamant, P.G. Krüger, B. Uvnäs

Open publisher page 121 citations

Abstract

Abstract Diamant, B., P. G. Krüger and B. Uvnäs. Local degranulation of individual rat peritoneal mast cells induced by compound 48/80. Acta physiol. scand. 1970. 79. 1–5. Degranulation of individual rat mast cells is shown to occur at the site of administration of compound 48/80 by the use of micropipets placed close to the mast cell membrane. Varying degree of degranulation can be induced. It is possible to induce repeated degranulation by local application of 48/80 to the same area of the cell at least four times. The results suggest that compound 48/80 acts directly on the cell membrane and this interaction seems to be the primary cause of the extrusion of granules.

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Abstract Diamant, B., P. G. Krüger and B. Uvnäs. Local degranulation of individual rat peritoneal mast cells induced by compound 48/80. Acta physiol. scand. 1970. 79. 1–5. Degranulation of individual rat mast cells is shown to occur at the site of administration of compound 48/80 by the use of micropipets placed close to the mast cell membrane. Varying degree of degranulation can be induced. It is possible to induce repeated degranulation by local application of 48/80 to the same area of the cell at least four times. The results suggest that compound 48/80 acts directly on the cell membrane and this interaction seems to be the primary cause of the extrusion of granules.

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Available abstract

Abstract Diamant, B., P. G. Krüger and B. Uvnäs. Local degranulation of individual rat peritoneal mast cells induced by compound 48/80. Acta physiol. scand. 1970. 79. 1–5. Degranulation of individual rat mast cells is shown to occur at the site of administration of compound 48/80 by the use of micropipets placed close to the mast cell membrane. Varying degree of degranulation can be induced. It is possible to induce repeated degranulation by local application of 48/80 to the same area of the cell at least four times. The results suggest that compound 48/80 acts directly on the cell membrane and this interaction seems to be the primary cause of the extrusion of granules.

Key concepts: Degranulation, Compound 48/80, Mast cell, Chemistry, Immunology, Cell, Cell biology, Pharmacology

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