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1961•Acta Physiologica ScandinavicaRequires access

Evidence for Energy‐Requiring Processes in Histamine Release and Mast Cell Degranulation in Rat Tissues Induced by Compound 48/80

Bertil Diamant, Börje Uvnäs

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Abstract

Abstract Histamine release from rat lung tissue and degranulation of rat mesentery mast cells were produced in vitro by Compound 48/80. Both processes were shown to be blocked by anoxia and by inhibitors of oxidative phosphorylation. Preincubation with glucose counteracted this inhibition. The results indicate that histamine release and mast cell degranulation require energy which can derive from glucose metabolism.

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Abstract Histamine release from rat lung tissue and degranulation of rat mesentery mast cells were produced in vitro by Compound 48/80. Both processes were shown to be blocked by anoxia and by inhibitors of oxidative phosphorylation. Preincubation with glucose counteracted this inhibition. The results indicate that histamine release and mast cell degranulation require energy which can derive from glucose metabolism.

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Available abstract

Abstract Histamine release from rat lung tissue and degranulation of rat mesentery mast cells were produced in vitro by Compound 48/80. Both processes were shown to be blocked by anoxia and by inhibitors of oxidative phosphorylation. Preincubation with glucose counteracted this inhibition. The results indicate that histamine release and mast cell degranulation require energy which can derive from glucose metabolism.

Key concepts: Degranulation, Histamine, Compound 48/80, Mast cell, Oxidative phosphorylation, In vitro, Chemistry, Liberation

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Evidence for Energy‐Requiring Processes in Histamine Release and Mast Cell Degranulation in Rat Tissues Induced by Compound 48/80 — Research Paper | ScholarLens