2010•Drug Metabolism and DispositionRequires access

Cytochrome P450 3A4 mRNA Is a More Reliable Marker than CYP3A4 Activity for Detecting Pregnane X Receptor-Activated Induction of Drug-Metabolizing Enzymes

Odette A. Fahmi, Mary Kish, Sherri Boldt, R. Scott Obach

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Key concepts: CYP3A4, Constitutive androstane receptor, CYP2B6, Enzyme inducer, Pregnane X receptor, Cytochrome P450, Drug metabolism, Isozyme

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Cytochrome P450 3A4 mRNA Is a More Reliable Marker than CYP3A4 Activity for Detecting Pregnane X Receptor-Activated Induction of Drug-Metabolizing Enzymes — Research Paper | ScholarLens