2017•PhytomedicineRequires access

Modulation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation by ursolic acid (UA) attenuates rifampin-isoniazid cytotoxicity

Hsiao‐Yun Chang, Chao‐Jung Chen, Wei-Chih Ma, Wai-Kok Cheng, Yen-Ning Lin, Ying‐Ray Lee, Jih‐Jung Chen, Yun-Ping Lim

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Key concepts: Pregnane X receptor, Constitutive androstane receptor, CYP3A4, Transactivation, Nuclear receptor, Chemistry, Pharmacology, Cytochrome P450