2013•Journal of Cancer Research and TherapeuticsOpen access

The expression of Heparanase mRNA and its clinical significance in Hepatocellular carcinoma

Yu Shen, Qiang Wang, Peng Wang, Xiaowei Li

Abstract

OBJECTIVE: To investigate the clinico-pathologic importance of Heparanase mRNA expression in hepatocellular carcinoma and its relationship with prognosis. MATERIALS AND METHODS: Fresh tumors and noncancerous liver tissues were obtained from 30 hepatocellular carcinoma patients after hepatectomy. Expression levels of Heparanase and glyceraldehyde-3-phosphate dehydrogenase mRNA were quantitatively analyzed by real-time reverse transcriptase-polymerase chain reaction. RESULTS: The relative Heparanase mRNA expression level (Heparanase: glyceraldehyde-3-phosphate dehydrogenase ratio) in hepatocellular carcinoma was lower than that in noncancerous tissue (P < 0.05). CONCLUSION: Reduced Heparanase mRNA expression might result in abnormal cell growth and correlate with hepatocellular carcinoma progression.

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Key concepts: Heparanase, Hepatocellular carcinoma, Messenger RNA, Reverse transcriptase, Cancer research, Glyceraldehyde 3-phosphate dehydrogenase, Real-time polymerase chain reaction, Carcinoma