1981•Antimicrobial Agents and ChemotherapyOpen access

Serum Bactericidal Activity of Moxalactam and Cefotaxime With and Without Tobramycin Against Pseudomonas aeruginosa and Staphylococcus aureus

Hjalmar Lagast, Stephen H. Zinner, Jean Klášterský

Abstract

Serum bactericidal activity was determined against 10 strains each of Pseudomonas aeruginosa and Staphylococcus aureus in serum from volunteers 1 and 6 h after intravenous infusion of cefotaxime, tobramycin, and the combination; or of moxalactam, tobramycin, and the combination. High serum bactericidal activity against P. aeruginosa was found significantly more frequently with moxalactam plus tobramycin than with cefotaxime, moxalactam, and tobramycin alone or with cefotaxime plus tobramycin.

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Available abstract

Key concepts: Tobramycin, Moxalactam, Cefotaxime, Pseudomonas aeruginosa, Staphylococcus aureus, Microbiology, Latamoxef, Antibiotics