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2009•ChemotherapyRequires access

Comparative in vitro Activity of 5 Cephalosporins with Other Antibiotics Tested against 887 Recent Clinical Isolates

Benedict L. Wasilauskas

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Abstract

Five cephalosporins including 3 newer agents were tested along with several aminoglycosides, penicillins and other antimicrobials against 887 recent clinical bacterial isolates. Of the newer cephalosporins, cefotaxime appeared to be the most effective against gram-negative bacilli. However, with gram-positive cocci, cephalothin seemed to be the most effective cephalosporin. Superior antipseudomonal activity still resides with the aminoglycosides although moxalactam and cefotaxime appeared to offer some alternatives.

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What this paper is about

Five cephalosporins including 3 newer agents were tested along with several aminoglycosides, penicillins and other antimicrobials against 887 recent clinical bacterial isolates. Of the newer cephalosporins, cefotaxime appeared to be the most effective against gram-negative bacilli. However, with gram-positive cocci, cephalothin seemed to be the most effective cephalosporin. Superior antipseudomonal activity still resides with the aminoglycosides although moxalactam and cefotaxime appeared to offer some alternatives.

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OpenAlex reports 4 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Five cephalosporins including 3 newer agents were tested along with several aminoglycosides, penicillins and other antimicrobials against 887 recent clinical bacterial isolates. Of the newer cephalosporins, cefotaxime appeared to be the most effective against gram-negative bacilli. However, with gram-positive cocci, cephalothin seemed to be the most effective cephalosporin. Superior antipseudomonal activity still resides with the aminoglycosides although moxalactam and cefotaxime appeared to offer some alternatives.

Key concepts: Cefotaxime, Cephalosporin, Moxalactam, Microbiology, Antibiotics, Bacilli, Antimicrobial, Medicine

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