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Effect of Phenylalanine and Its Metabolites on the Brain Serotonin Level of the Rat.

William J. Culley, R. N. Saunders, E. T. Mertz, Dean Jolly

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Abstract

Wistar rats were placed on diets supplemented with 7% phenylalanine, 4.5% phenylpyruvic acid, 3% ortho-hydroxyphenylacetic acid or 4% phenylacetic acid. Analysis of brain samples for serotonin after several days on these diets showed that phenylalanine feeding effectively lowered brain serotonin, phenylpyruvic acid feeding did so less effectively, and phenylacetic acid and o-hydroxyphenylacetic acid feeding caused no significant change. The implications of these findings in relation to the treatment of phenylketonuria are discussed.

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What this paper is about

Wistar rats were placed on diets supplemented with 7% phenylalanine, 4.5% phenylpyruvic acid, 3% ortho-hydroxyphenylacetic acid or 4% phenylacetic acid. Analysis of brain samples for serotonin after several days on these diets showed that phenylalanine feeding effectively lowered brain serotonin, phenylpyruvic acid feeding did so less effectively, and phenylacetic acid and o-hydroxyphenylacetic acid feeding caused no significant change. The implications of these findings in relation to the treatment of phenylketonuria are discussed.

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Available abstract

Wistar rats were placed on diets supplemented with 7% phenylalanine, 4.5% phenylpyruvic acid, 3% ortho-hydroxyphenylacetic acid or 4% phenylacetic acid. Analysis of brain samples for serotonin after several days on these diets showed that phenylalanine feeding effectively lowered brain serotonin, phenylpyruvic acid feeding did so less effectively, and phenylacetic acid and o-hydroxyphenylacetic acid feeding caused no significant change. The implications of these findings in relation to the treatment of phenylketonuria are discussed.

Key concepts: Phenylpyruvic acid, Phenylacetic acid, Phenylalanine, Serotonin, Chemistry, Endocrinology, Internal medicine, Biochemistry

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