1984•Antimicrobial Agents and ChemotherapyOpen access

Ketoconazole in the prevention of experimental candidal vaginitis

Jack D. Sobel, Gregory Muller

Abstract

The prophylactic and therapeutic activities of ketoconazole were evaluated in rats inoculated intravaginally with Candida albicans. Daily doses of 2.5 mg/kg initiated 48 h before challenge and continued for 48 h thereafter protected 80% of the rats against infection. A similar result in rats with established infection was attained with daily doses of 5.0 mg/kg.

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Available abstract

Key concepts: Ketoconazole, Candida albicans, Vaginitis, Medicine, Pharmacology, Mycosis, Microbiology, Antifungal