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1996•Journal of Biological ChemistryOpen access

Biosynthesis of Apolipoprotein B48-containing Lipoproteins

Thomas L. Innerarity, Jan Borén, Shinya Yamanaka, Sven‐Olof Olofsson

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Abstract

Apolipoprotein (apo) (1) B plays a central role in lipoprotein metabolism. It is the only apolipoprotein in low density lipoproteins (LDL), the lipoproteins that transport two-thirds of the plasma cholesterol in humans. Elevated concentrations of LDL cholesterol are one of the major risk factors for the development of atherosclerosis. The possibility of lowering plasma LDL concentrations by limiting the production of very low density lipoproteins (VLDL), the precursor of LDL, has fueled interest in the biosynthesis of VLDL.

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What this paper is about

Apolipoprotein (apo) (1) B plays a central role in lipoprotein metabolism. It is the only apolipoprotein in low density lipoproteins (LDL), the lipoproteins that transport two-thirds of the plasma cholesterol in humans. Elevated concentrations of LDL cholesterol are one of the major risk factors for the development of atherosclerosis. The possibility of lowering plasma LDL concentrations by limiting the production of very low density lipoproteins (VLDL), the precursor of LDL, has fueled interest in the biosynthesis of VLDL.

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OpenAlex reports 129 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Apolipoprotein (apo) (1) B plays a central role in lipoprotein metabolism. It is the only apolipoprotein in low density lipoproteins (LDL), the lipoproteins that transport two-thirds of the plasma cholesterol in humans. Elevated concentrations of LDL cholesterol are one of the major risk factors for the development of atherosclerosis. The possibility of lowering plasma LDL concentrations by limiting the production of very low density lipoproteins (VLDL), the precursor of LDL, has fueled interest in the biosynthesis of VLDL.

Key concepts: Very low-density lipoprotein, Apolipoprotein B, Intermediate-density lipoprotein, Apolipoprotein C2, Cholesterol, Internal medicine, Chemistry, Biosynthesis

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