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1969•EndocrinologyRequires access

Effect of High Sodium Intake on the Response of the Rat Adrenal to Angiotensin II

Maria Dufau, John D. Crawford, Bernard Kliman

Open publisher page 8 citations

Abstract

The adrenal glands of intact male rats fed a high sodium diet have a normal content of corticosterone and a low content of aldosterone. A low sodium diet is associated with a reduction of corticosterone and a marked increase in aldosterone. Chronic angiotensin treatment which has been previously shown to stimulate secretion of aldosterone and corticosterone is ineffective in the presence of a high sodium diet. Dietary sodium plays a significant role in the response of the rat adrenal to angiotensin. (Endocrinology84: 462, 1969)

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The adrenal glands of intact male rats fed a high sodium diet have a normal content of corticosterone and a low content of aldosterone. A low sodium diet is associated with a reduction of corticosterone and a marked increase in aldosterone. Chronic angiotensin treatment which has been previously shown to stimulate secretion of aldosterone and corticosterone is ineffective in the presence of a high sodium diet. Dietary sodium plays a significant role in the response of the rat adrenal to angiotensin. (Endocrinology84: 462, 1969)

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Available abstract

The adrenal glands of intact male rats fed a high sodium diet have a normal content of corticosterone and a low content of aldosterone. A low sodium diet is associated with a reduction of corticosterone and a marked increase in aldosterone. Chronic angiotensin treatment which has been previously shown to stimulate secretion of aldosterone and corticosterone is ineffective in the presence of a high sodium diet. Dietary sodium plays a significant role in the response of the rat adrenal to angiotensin. (Endocrinology84: 462, 1969)

Key concepts: Corticosterone, Aldosterone, Internal medicine, Endocrinology, Sodium, Angiotensin II, Renin–angiotensin system, Mineralocorticoid

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