1990•Endocrine ResearchRequires access

Amplification of Mineralocorticoid Activity of Aldosterone by 18–Hydroxy-Corticosterone and 18-Hydroxy-19-Nor-Corticosterone in Adrenalectomized Rats

T. Rosenthal, Michal Shani, Edna Peleg, M. Harnik

Abstract

A combination of aldosterone (1 micrograms) with either 18-OH-corticosterone (1 micrograms) or 18-OH-19-norcorticosterone (1 micrograms) injected to adrenalectomized rats indicated an amplification of mineralocorticoid activity as expressed by Na/K ratio in urine. Without aldosterone their mineralocorticoid potency was negligible.

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Key concepts: Corticosterone, Aldosterone, Endocrinology, Internal medicine, Mineralocorticoid, Potency, Adrenalectomy, Chemistry