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2012•Bioorganic & Medicinal Chemistry LettersOpen access

Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity

Gary E. Keck, Yam B. Poudel, Arnab Rudra, Jeffrey C. Stephens, Noémi Kedei, Nancy E. Lewin, Peter M. Blumberg

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Key concepts: Bryostatin 1, Chemistry, Biological activity, Protein kinase C, Chemical synthesis, In vitro, Downregulation and upregulation, Isozyme

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