2009•Chemical CommunicationsRequires access

Catalytic C–H amination: recent progress and future directions

Florence Collet, Robert H. Dodd, Philippe Dauban

Open publisher page 798 citations

Abstract

Recent developments in catalytic C-H amination are discussed in this feature article. The careful design of reagents and catalysts now provides efficient conditions for exquisitely selective intramolecular as well as intermolecular nitrene C-H insertion. The parallel emergence of C-H activation/amination reactions opens new opportunities complementary to those offered by nitrenes.

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What this paper is about

Recent developments in catalytic C-H amination are discussed in this feature article. The careful design of reagents and catalysts now provides efficient conditions for exquisitely selective intramolecular as well as intermolecular nitrene C-H insertion. The parallel emergence of C-H activation/amination reactions opens new opportunities complementary to those offered by nitrenes.

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Available abstract

Recent developments in catalytic C-H amination are discussed in this feature article. The careful design of reagents and catalysts now provides efficient conditions for exquisitely selective intramolecular as well as intermolecular nitrene C-H insertion. The parallel emergence of C-H activation/amination reactions opens new opportunities complementary to those offered by nitrenes.

Key concepts: Nitrene, Amination, Catalysis, Intramolecular force, Combinatorial chemistry, Intermolecular force, Chemistry, Reagent

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