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1983•Journal of Labelled Compounds and RadiopharmaceuticalsRequires access

Tritium labelling of benzamide drugs

Ilan Pri‐Bar, O. Buchman

Open publisher page 10 citations

Abstract

Abstract Methods for tritiation of sulpiride, sultopride and metoclopramide were developed and optimized. 3H‐sulpiride (7.1 Ci/mmol), 3H‐sultopride (2.1 Ci/mmol) and 3H‐metoclopramide (18.0 Ci/mmol) were obtained by hydrodebromination of the related bromo derivatives. The bromo derivatives were prepared, in turn, by appropriate procedures specified for each case.

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What this paper is about

Abstract Methods for tritiation of sulpiride, sultopride and metoclopramide were developed and optimized. 3H‐sulpiride (7.1 Ci/mmol), 3H‐sultopride (2.1 Ci/mmol) and 3H‐metoclopramide (18.0 Ci/mmol) were obtained by hydrodebromination of the related bromo derivatives. The bromo derivatives were prepared, in turn, by appropriate procedures specified for each case.

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Available abstract

Abstract Methods for tritiation of sulpiride, sultopride and metoclopramide were developed and optimized. 3H‐sulpiride (7.1 Ci/mmol), 3H‐sultopride (2.1 Ci/mmol) and 3H‐metoclopramide (18.0 Ci/mmol) were obtained by hydrodebromination of the related bromo derivatives. The bromo derivatives were prepared, in turn, by appropriate procedures specified for each case.

Key concepts: Benzamide, Chemistry, Sulpiride, Metoclopramide, Labelling, Tritium, Radiochemistry, Chromatography

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