2005•Chinese Journal of Cancer ResearchRequires access
Expression and clinical significance of E2F-3 and Bcl-2 in hepatocellular carcinoma
Xin-hua Ju, Jiyang Zhang, Zhen-long Xia
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Abstract
Objective: To investigate the expression of E2F and Bcl-2 and the clinicopathological significance in hepatocellular carcinoma. Methods: The expressions of E2F-3 and Bcl-2 in 74 patients with hepatic carcinoma, paracarcinoma and 15 patients with liver cirrhosis were detected by S-P immunohistochemical staining. Results: The expression of E2F in hepatic carcinoma was significantly higher than that in paracarcinoma or liver cirrhosis (P<0.005), the expression of Bcl-2 in hepatic carcinoma was significantly higher than that in paracarcinoma (P<0.005), in which Bcl-2 expression was lower than in liver cirrhosis(P<0.05). The expression of E2F-3 was related with histological grade, tumor size, and the expression of Bcl-2 was related with histological grade, tumor size and tumor number. There was correlation between the expression of E2F-3 and Bcl-2 in hepatic carcinoma. Conclusion: E2F-3 and Bcl-2 expression may play an important role in development, progression and cell apoptosis of tumor.