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Effect of Sevidol on the Induction of Micronuclei in the Bone-Marrow Erythrocytes of Mice

Gursatej Dhingra, J. B. Chowdhury, P. K. Sareen

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Abstract

SUMMARYSevidol, an insecticidal mixture comprising carbaryl and lindane, was studied for genotoxicity evaluation in the bone-marrow erythrocytes of Swiss albino male mice. EMS was taken as the reference mutagen. Sevidol was dissolved in DMSO and three dose levels (1/10 LD50, 1/2 LD50, a dose close to LD50) were studied. Sevidol was found to increase the number of micronuclei significantly in the polychromatic erythrocytes at the three doses tested. A significant decrease in the number of polychromatic erythrocytes was also observed at the highest dose tested, indicating the toxic nature of the compound.

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SUMMARYSevidol, an insecticidal mixture comprising carbaryl and lindane, was studied for genotoxicity evaluation in the bone-marrow erythrocytes of Swiss albino male mice. EMS was taken as the reference mutagen. Sevidol was dissolved in DMSO and three dose levels (1/10 LD50, 1/2 LD50, a dose close to LD50) were studied. Sevidol was found to increase the number of micronuclei significantly in the polychromatic erythrocytes at the three doses tested. A significant decrease in the number of polychromatic erythrocytes was also observed at the highest dose tested, indicating the toxic nature of the compound.

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Available abstract

SUMMARYSevidol, an insecticidal mixture comprising carbaryl and lindane, was studied for genotoxicity evaluation in the bone-marrow erythrocytes of Swiss albino male mice. EMS was taken as the reference mutagen. Sevidol was dissolved in DMSO and three dose levels (1/10 LD50, 1/2 LD50, a dose close to LD50) were studied. Sevidol was found to increase the number of micronuclei significantly in the polychromatic erythrocytes at the three doses tested. A significant decrease in the number of polychromatic erythrocytes was also observed at the highest dose tested, indicating the toxic nature of the compound.

Key concepts: Micronucleus test, Genotoxicity, Bone marrow, Mutagen, Biology, Lindane, Carbaryl, Micronucleus

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Effect of Sevidol on the Induction of Micronuclei in the Bone-Marrow Erythrocytes of Mice — Research Paper | ScholarLens